Journal of Cutaneous and Aesthetic Surgery
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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 144-147
Laser: A powerful tool for treatment of pyogenic granuloma

Department of Oral Medicine and Radiology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar, Uttar Pradesh, India

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Date of Web Publication17-Sep-2011


Lasers have opened a new door for the treatment of various disorders. Treatment of soft tissue intraoral mucosal growth by laser has profound effect on the patient acceptability taking the functional and aesthetic factor into consideration. The patient is able to get the outdoor treatment without the phobia of local anaesthetic and is out of the clinic in few minutes in contrast to the traditional method of surgical excision. Very few cases have been reported in literature regarding treatment of mucosal growth by soft tissue lasers. We present a case of recurrent pyogenic granuloma in a patient treated with an alternative approach, that is, diode laser, without the use of anaesthesia, sutures, anti-inflammatory drugs, or analgesics. The diagnosis of this lesion is equally important for correct treatment planning.

Keywords: Diode laser, pyogenic granuloma, recurrent

How to cite this article:
Rai S, Kaur M, Bhatnagar P. Laser: A powerful tool for treatment of pyogenic granuloma. J Cutan Aesthet Surg 2011;4:144-7

How to cite this URL:
Rai S, Kaur M, Bhatnagar P. Laser: A powerful tool for treatment of pyogenic granuloma. J Cutan Aesthet Surg [serial online] 2011 [cited 2022 Aug 10];4:144-7. Available from:

   Introduction Top

Pyogenic granuloma is a relatively common benign mucocutaneous lesion. The term is a misnomer as the lesion does not contain pus nor it is granulomatous. It was originally described in 1897 by two French surgeons, Poncet and Dor. [1] It is considered as a capillary haemangioma of lobular subtype as suggested by Mills, Cooper, and Fechner, which is the reason they are often quite prone to bleeding. [2] The most common intraoral site is marginal gingiva, but lesions have been reported on palate, buccal mucosa, tongue, and lips. Extraoral sites commonly involve the skin of face, neck, upper and lower extremities, and mucous membrane of nose and eyelids.

Being a non-neoplastic growth, excisional therapy is the treatment of choice but some alternative approaches such as cryosurgery, excision by Nd:YAG Laser, flash lamp pulsed dye laser, injection of corticosteroid or ethanol, and sodium tetradecyl sulfate sclerotherapy have been reported to be effective. [1] There are only anecdotal reports of successful treatment of mucosal pyogenic granulomas with diode laser. In this report, we seek to highlight the therapeutic success achieved with diode laser in the treatment of intraoral pyogenic granuloma.

   Case Report Top

A 50-year-old female patient reported to the Out Patient Department of Oral Medicine and Radiology, with a complain of localized gingival growth for 3 months. The outgrowing mass was not painful but often bled while eating, rinsing, or sometimes spontaneously. Patient reported a similar growth in the gingiva about 3 years ago, which was treated in the same institute by surgical excision.

Intraoral examination revealed an oval-shaped, pedunculated mass-like growth seen in relation to the buccal aspect of gingiva with respect to 23, 24 region, measuring approximately 2.5 × 3.5 cm. This discrete nodular, erythematous enlargement was covering almost two-third of the crown of 24 [Figure 1]. On palpation, the mass was soft to firm in consistency and readily bled on probing. Oral hygiene was well maintained, and no exacerbating factors were identified. The previous biopsy specimen turned out to be 'pyogenic granuloma'. Based on the clinical findings and the previous biopsy report, the case was provisionally diagnosed as recurrent pyogenic granuloma.
Figure 1: A discrete nodular, erythematous enlargement covering almost two-third of the crown of 24

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No bony abnormalities were seen on intraoral periapical radiographic examination.

The lesion was treated by Soft-tissue Diode Laser manufactured by Picasso (Kavo, USA), with following specifications: wavelength 808 nm (± 10), output energy 0.1-7.0 W, and input power 300 VA. We used 810-nm wavelength and 7 W power, keeping it in continuous/interrupted pulse mode. Local anaesthesia was not used. The tip was kept at a distance of about 1 mm from the soft tissue throughout the procedure, and it took 4-5 min to completely excise the mass. The diode laser provided an optimum combination of clean cutting of the tissue and haemostasis [Figure 2] and [Figure 3]. Patient was discharged with all necessary post-operative instructions. She was not prescribed any antibiotics, analgesics, or anti-inflammatory medication and was subjected to routine scaling and curettage. She revisited after 5 days for follow-up visit, but failed to keep further appointments.
Figure 2: Diode laser (Picasso-KAVO)

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Figure 3: Tip was kept almost at a distance of 1 mm from the soft tissue. Also, there was minimal bleeding during the procedure

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The excised mass [Figure 4] was sent for histopathologic evaluation which showed hyperplastic stratified squamous parakeratotic epithelium with an underlying fibrovascular stroma. The stroma consisted of a large number of budding and dilated capillaries, plump fibroblasts and areas of extravasated blood, and a dense chronic inflammatory cell infiltrate. The above histopathologic features were suggestive of pyogenic granuloma [Figure 5].
Figure 4: Excisional biopsy specimen

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Figure 5: Photomicrograph of histopathological section under low magnification (10×)

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   Discussion Top

Although pyogenic granuloma may appear at any age, 60% cases are observed between the ages of 10 and 40; incidence peaks during the third decade of life and women are twice as likely to be affected. It is more common in children and young adults. [3]

The clinical presentation is generally of a dull red, sessile, or pedunculated smooth surfaced nodule that may easily bleed, crust, or ulcerate. Lesions may grow rapidly, reach its maximum size, and remain static. [4] They may typically begin as small, red papules that rapidly enlarge to become pedunculated raspberry-like nodules. Rarely, patient may develop multiple satellite angiomatous lesions after excision of a solitary pyogenic granuloma.

Oral pyogenic granulomas show a striking predilection for the gingiva as seen in the present case, which accounts for 75% of all cases. Gingival irritation and inflammation that result from poor oral hygiene may be a precipitating factor in many patients. The lip, tongue, and buccal mucosa are the next most common sites. [5],[6]

In majority of cases, minor trauma and/or chronic irritation are cited in the etiopathogenesis of pyogenic granuloma. [7] Infection may play a role with suggestions of agents such as streptococci and staphylococci. [8] Recently, angiopoietin-1,2 and ephrin B2 [9] agents in other vascular tumours such as Bartonella henselae, B. quintana, and human herpes virus 8 have been postulated to play a part in recurrent pyogenic granuloma. [10] Multiple pyogenic granulomas with satellite lesions may occur as a complication of tumour removal or trauma. [11] Viral oncogenes, hormonal influences, microscopic arteriovenous malformation along with inclusion bodies and gene depression in fibroblasts have all been implicated. [12],[13]

Differential diagnosis of pyogenic granuloma includes haemangioma, [5] peripheral giant cell granuloma, peripheral ossifying fibroma and metastatic carcinoma, and amelanotic melanoma. [6]

Although the conventional treatment for pyogenic granuloma is surgical excision, a recurrence rate of 16% has been reported. [14] There are also reports of the lesion being eliminated with electric scalpel or cryosurgery. [15] Other methods used by various workers include cauterization with silver nitrate, sclerotherapy with sodium tetra decyl sulfate and monoethanolamineoleate [16] ligation, absolute ethanol injection dye, [17] Nd:YAG and CO 2 laser, [18] shave excision, and laser photocoagulation. [19]

Laser therapy using continuous and pulsed CO 2 and Nd:YAG systems have been used for a variety of intraoral soft tissue lesions such as haemangioma, lymphangioma, squamous papilloma, lichen planus, focal melanosis, and pyogenic granuloma, because they carry the advantage of being less invasive and sutureless procedures that produce only minimal postoperative pain. Rapid healing can be observed within a few days of treatment, and as blood vessels are sealed, there are both a reduced need for post-surgical dressings and improved haemostasis and coagulation. It also depolarizes nerves, thus reducing post-operative pain, and also destroys many bacteria and viral colonies that may potentially cause infection. Reduced post-operative discomfort, oedema, scarring, and shrinkage have all been associated with its use. [19]

White et al proposed that laser excision is well tolerated by patients with no adverse effects. They also stated that CO 2 and Nd:YAG Laser irradiation is successful in surgical treatment. [1] Meffert et al used the flash lamp pulsed dye laser on a mass of granulation tissue and concluded that previously resolute tissue responded well to the series of treatments with pulsed dye laser. [1] Diode laser has shown excellent results in cutaneous pyogenic granulomas with only minimal pigmentary and textural complications. Gonzales et al[21] demonstrated both symptomatic and clinical clearing of the lesions with excellent cosmetic results in 16 of 18 treated patients. However, there is minimal convincing proof of its efficacy in intraoral pyogenic granuloma. We achieved complete resolution of this lesion located on the upper gingiva with diode laser without producing any complications. There was no scarring or recurrence. Hence, diode laser may be a good therapeutic option for intraoral pyogenic granulomas.

In conclusion, the use of laser offers a new tool that can change the way in which existing treatments are performed, or serve to compliment them. Modern medicine needs to explore and take advantage of current trends to derive maximum benefit in terms of technology, patient's acceptance and, post-operative management.

   References Top

1.Jaferzadeh H, Sanadkhani M, Mohtasham M. Oral pyogenic granuloma: A review. J Oral Sci 2006;48:167-75.  Back to cited text no. 1
2.Shafer, Hine, Levy. In: Textbook of oral pathology. 5 th ed. the Netherlands: Elsevier Publication; 2006. p. 994-7.  Back to cited text no. 2
3.Nthumba PM. Giant pyogenic granuloma of the thigh: A case report. J Med Case Rep 2008;2:95. Available from:  Back to cited text no. 3
4.Neville BW, Damm DD, Allen CM, Bouquet JE. In: Oral and maxillofacial pathology 3 rd ed. the Netherlands: Elsevier; 2004. p. 176-7.  Back to cited text no. 4
5.Wood NK, Goaz PW. In: Textbook of differential diagnosis of oral and maxillofacial lesions, USA: Mosby; 5 th ed, 1997. p. 32-4.   Back to cited text no. 5
6.Greenberg MS, Glick M, Ship JA. In: Burkett's textbook of oral medicine. 11 th ed. USA: BC Becker Inc; 2008. p. 131-2.  Back to cited text no. 6
7.MacLeod RL, Soames J. Epilides: A clinicopathological study of 200 consecutive lesions. Br Dent J 1987;163:51-3.  Back to cited text no. 7
8.Levy I, Rolain JM, Lepidi H. Is pyogenic granuloma associated with Bartonella infection? J Am Acad Dermatol 2005;53:1065-6.  Back to cited text no. 8
9.Yuan K, Jin YT, Lin MT. Expression of tie-2, angiopoietin-1, angiopoientin -2, Ephrin B2 and EphB4 in pyogenic granuloma of human gingival implicates their roles in inflammatory angiogenesis. J Periodont Res 2000;35:165-71.  Back to cited text no. 9
10.Janier M. Infection and angiomatous cutaneous lesions. J Mal Vasc 1999;24:135-8.  Back to cited text no. 10
11.Taira JW, Hill TL, Everett MA. Lobular capillary hemangioma (pyogenic granuloma) with satellitosis. J Am Acad Dermatol 1992;27:297-300.  Back to cited text no. 11
12.Davies MG, Borton SP, Atai F. The abnormal dermis in pyogenic granuloma. J Am Acad Dermatol 2001;31:342-4.  Back to cited text no. 12
13.Vilman A, Vilman P, Vilman H. Pyogenic granuloma. Evaluation of oral conditions. Dr J Oral Maxillfac Surg 1986;24:376.  Back to cited text no. 13
14.Newman, Takei, Carranza. In: Textbook of Carranza's clinical periodontology, 10 th ed. the Netherlands: Elsevier Publication, 2006, p:176-77  Back to cited text no. 14
15.Gupta R, Gupta S. Cryo-therapy in granuloma pyogenicum. Indian J Dermatol Venereol Leprol 2007;73:14.  Back to cited text no. 15
16.Matsumoto K, Nakanishi H, Seike T. Treatment of pyogenic granuloma with sclerosing agents. Dermatol Surgery 2001;27:521-3.  Back to cited text no. 16
17.Ichimiya M, Yoshikawa K, Hamamoto Y, Muto M. Successful treatment of pyogenic granuloma with injection of absolute alcohol. J Dermatol 2001;31:342-4.  Back to cited text no. 17
18.Raulin C, Greve B, Hammes S. The combined continuous-wave/pulsed carbon dioxide laser for treatment of pyogenic granuloma. Arch Dermatol 2002;138:33-7.  Back to cited text no. 18
19.Kirschner RE, Low DW. Treatment of pyogenic granuloma by shave excision and laser photocoagulation. Plast Reconstr Surg 1999;104:1346-69.  Back to cited text no. 19
20.Boj JR, Hernandez M, Poirier C, Espasa E. Treatment of pyogenic granuloma with a laser - powered Hydrokinetic system: Case report. J Oral Laser Appl 2006;6:301-6.  Back to cited text no. 20
21.Gonzales S, Vibhagool C, Falo LD Jr, Momtaz KT, Grevelink J, Gonzalez E. Treatment of pyogenic granulomas with the 585nm pulsed dye laser. J Am Acad Dermatol 1996;35:428-31. phosphatidyl choline and deoxycholate (50 mg/ml)  Back to cited text no. 21

Correspondence Address:
Shalu Rai
Department of Oral Medicine and Radiology, Institute of Dental Studies and Technologies, Kadrabad, Modinagar - 201 201, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-2077.85044

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  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]

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