Journal of Cutaneous and Aesthetic Surgery
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Year : 2022  |  Volume : 15  |  Issue : 1  |  Page : 17-23

To compare the efficacy and safety of autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting (Jodhpur technique) with autologous platelet-rich fibrin matrix (PRFM) in the treatment of chronic non-healing ulcer

Department of Dermatology, Dr S. N. Medical College, Jodhpur, Rajasthan, India

Correspondence Address:
Dr. Dilip Kachhawa
Bunglow No. 3, Outside Gate No. 1, MDM Hospital, Jodhpur, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCAS.JCAS_196_20

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Background: Chronic non-healing ulcers (NHUs) are often associated with some underlying pathology which prevents timely healing thus increasing the patients morbidity and healthcare expenses. Autologous non-cultured non-trypsinized keratinocyte and melanocyte grafting also known as Jodhpur technique (JT), an epidermal graft and autologous platelet-rich fibrin matrix (PRFM) are newer modalities with promising results. Aims: To compare the efficacy and safety of JT and autologous PRFM in the treatment of chronic NHU. Design: A prospective hospital based interventional study conducted on 50 patients of chronic NHU attending the dermatology outdoor of a tertiary level government hospital. Materials and Methods: After taking clearance from the institutional ethical committee, the patients were enrolled into 2 groups of 25 each. JT was done on group A and autologous PRFM on group B and their efficacy and safety compared. Statistical Analysis: Chi square test was used to analyze categorical variables summarized as number and percentage while continuous variables were analyzed using student t-test for intergroup comparison. Results: In Group A, the mean time to ulcer healing was 6.17 ± 2.17 weeks while 6.43 ± 2.33 weeks in Group B. No side effects were found in either group. Conclusion: Both the techniques fair equally in terms of wound healing time and safety but required multiple sittings in group B and a single session in group A.

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